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. 2014 Feb 20;10(2):e1004132. doi: 10.1371/journal.pgen.1004132

Figure 4. Genotype-Metabotype-Phenotype associations.

Figure 4

The two novel gene-metabolite associations of this study implicate SNPs that had previously been associated with disease-related phenotypes by the indicated publications: (A) Fucose–Crohn's disease–FUT2 (rs492602), (B) Lysine–eGFR–SLC7A9 (rs8101881). A link between the metabolite and the phenotype has been established for (A) based on a mouse model and for (B) by a direct correlation with the indicated significance and effect size. Abbreviations: OR refers to the odds ratio, x to the linear regression effect size, P to the corresponding P-value, and the m-index indicates values obtained in the combined CoLaus and TasteSensomics sample.