Table 1. Single and multiple drug dosages evaluated in vivo against mature adults of T. muris, classified by route of administration.
Dosage (mg/kg) | 0.5 | 1.0 | 2.5 | 5.0 | 7.5 | 10 | 15 | 20 | 25 | 50 | 75 | 100 | 150 | 200 | 250 | 300 | 400 | 500 | |
PF1022A | 3×oral | X | X | X | X | X | X | X | X | ||||||||||
1× oral | X | X | X | X | X | X | X | X | |||||||||||
3× subcutaneous | X | X | X | X | X | X | X | X | |||||||||||
3× intraperitoneal | X | X | X | X | X | X | X | X | |||||||||||
Emodepside | 3× oral | X | X | X | X | X | X | X | X | ||||||||||
3× subcutaneous | X | X | X | X | X | X | X | X | |||||||||||
3× intraperitoneal | X | X | X | X | X | X | X | X | |||||||||||
Amidantel | 3× oral | X | |||||||||||||||||
3× subcutaneous | |||||||||||||||||||
3× intraperitoneal | |||||||||||||||||||
dAMD | 3× oral | X | X | X | X | X | X | ||||||||||||
3× subcutaneous | X | X | |||||||||||||||||
3× intraperitoneal | X | X | X | X | X | ||||||||||||||
Tribendimidine | 3× oral | X | X | X | X | X | X | ||||||||||||
3× subcutaneous | X | X | |||||||||||||||||
3× intraperitoneal | X | X | X | X | X |
‘X’ indicated that the respective drug was evaluated in the given dose using the indicated route of administration.