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. 2014 Feb 15;14:92. doi: 10.1186/1471-2407-14-92

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Copyright © 2014 Hompland et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DW-MRI, hypoxia, and IFP data for A-07 and R-18 melanoma xenografts showing that ADC decreased with increasing HF_Pimand increasing IFP. Histological sections of a representative A-07 tumor (A) and a representative R-18 tumor (B) stained with anti-pimonidazole antibody to visualize hypoxic tissue, plots of median ADC versus HF_Pim for A-07 (C) and R-18 (D) tumors, and plots of median ADC versus IFP for A-07 (E) and R-18 (F) tumors. Points represent single tumors. Curves were fitted to data by regression analysis.