Table 4.
Summary of cumulative 42-day release and aggregation behavior of lysozyme from implants prepared from di-block copolymers blended with PLGA (50/50) at 1:1 weight ratio with or without 3% MgCO3.
| Polymer Name | Lysozyme (%) | MgCO3 (%) | Cumulative Release (%) | Soluble Residue (%) | Insoluble Aggregates (%) | Recovery (%) |
|---|---|---|---|---|---|---|
| AB10-PLGA | 15 | 0 | 100 ± 3 | 0.3 ± 0.1 | 5.9 ± 0.4 | 106 ± 3 |
| AB10-PLGA | 15 | 3 | 88 ± 1 | 0.6 ± 0.1 | 6.5 ± 0.5 | 95 ± 1 |
| AB15-PLGA | 15 | 0 | 71 ± 4 | 0.7 ± 0.2 | 14 ± 2 | 86 ± 4 |
| AB15-PLGA | 15 | 3 | 90 ± 4 | 0 | 2.9 ± 0.7 | 92 ± 4 |