Table 5.
Summary of initial rate constants for polymer degradation in blank implants and in implants with encapsulated lysozyme, with or without MgCO3, measured by GPC.
| Polymer Name | Lysozyme (%) | MgCO3 (%) | Initial rate constant (day -1) |
|---|---|---|---|
| AB10 | 0 | 0 | 0.075±0.003 |
| AB15 | 0 | 0 | 0.104±0.002 |
| ABA10 | 0 | 0 | 0.116±0.002 |
| PLGA | 0 | 0 | 0.120±0.002 |
| AB10-PLGA a | 0 | 0 | 0.110±0.002 |
| AB15-PLGA a | 0 | 0 | 0.117±0.004 |
| AB10 | 15 | 0 | 0.047±0.002 |
| AB10 | 15 | 3 | 0.050±0.003 |
| AB15 | 15 | 0 | 0.023±0.001 |
| AB15 | 15 | 3 | 0.039±0.002 |
| ABA10 | 15 | 0 | 0.094±0.002 |
| ABA10 | 15 | 3 | 0.053±0.002 |
| PLGA | 15 | 0 | 0.034±0.003 |
| PLGA | 15 | 3 | 0.015±0.001 |
| AB10-PLGA a | 15 | 0 | 0.050±0.006 |
| AB10-PLGA a | 15 | 3 | 0.029±0.003 |
| AB15-PLGA a | 15 | 0 | 0.056±0.003 |
| AB15-PLGA a | 15 | 3 | 0.028±0.001 |
a
Block copolymers were blended with PLGA 50/50 at a 1:1 w/w ratio.