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. 2014 Feb 20;9(2):e89101. doi: 10.1371/journal.pone.0089101

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The template VOI mask for carotid and surrounding tissue was obtained from the spatially normalized (a) and averaged weighting parameter image for blood (b). Individual VOI masks for carotid and surrounding tissue were created by inverse spatial normalization of the template VOI mask (c). The inverse normalization parameters were derived from the spatial normalization of the average image of dynamic positron emission tomography (PET) to the ligand specific PET template.