Table 1. Biometric data and parameters of cardio-vascular function measured using echocardiography and conductance catheter.
| Non-pregnant sham (n) | Non-pregnant TAC (n) | Pregnant sham (n) | Pregnant TAC (n) | |
| Body weight (g) | 220±7 (11) | 226±6 (11) | 274±6*† (11) | 272±10*† (9) |
| Left ventricular weight (mg) | 423±15 (9) | 538±37* (10) | 389±13† (9) | 572±39*‡ (7) |
| Heart rate (/min) | 408±12 (10) | 425±10 (10) | 426±9 (11) | 421±10 (8) |
| Fractional shortening (%) | 45±3 (9) | 49±3 (9) | 49±1 (10) | 47±3 (9) |
| Cardiac output (mL/min) | 64±3 (8) | 68±3 (8) | 69±4 (10) | 65±5 (8) |
| Left ventricular inner diameter in diastole (mm) | 6.4±0.1 (9) | 6.3±0.1 (9) | 6.3±0.1 (10) | 6.3±0.2 (9) |
| Left ventricular relative wall thickness (%) | 43±3 (9) | 54±3 (9) | 49±1 (10) | 56±6 (9) |
| Calculated left ventricular mass (mg) | 544±25 (9) | 704±53 (9) | 625±25 (10) | 714±57* (9) |
| Left ventricular posterior wall thickness in diastole (mm) | 1.51±0.10 (9) | 1.82±0.11 (9) | 1.62±0.06 (10) | 1.78±0.20 (9) |
| Sum of septum and posterior wall thickness in diastole (mm) | 2.77±0.12 (9) | 3.40±0.16 (9) | 3.11±0.06 (10) | 3.44±0.24* (9) |
| Total peripheral resistance (mmHg*min/mL) | 1.68±0.13 (8) | 1.92±0.18 (8) | 1.20±0.08† (10) | 1.83±0.12‡ (6) |
| dP/dtmax (mmHg/sec*103) | 10.9±0.7 (11) | 10.8±0.6 (8) | 7.7±1.1* (6) | 11.0±0.7 (5) |
| dP/dtmin (mmHg/sec*103) | −12.2±0.9 (11) | −13.2±0.6 (8) | −8.7±1.3† (6) | −15.9±1.3‡ (5) |
| Isovolumetric relaxation constant (msec) | 10.6±1.0 (11) | 10.2±0.6 (9) | 10.1±0.6 (6) | 8.8±0.2 (5) |
| Arterial elastance (mmHg/mL) | 0.83±0.06 (9) | 0.98±0.09 (7) | 0.58±0.02† (5) | 1.24±0.11*‡ (5) |
| End-systolic elastance (mmHg/mL) | 2.05±0.25 (9) | 4.37±1.3 (7) | 2.31±0.30 (5) | 5.23±1.5 (5) |
Data are presented as mean±SEM. Comparisons between groups were made using one-way ANOVA and Holm-Sidak post hoc test. TAC, transverse aorta constriction. n, number of animals. p<0.05 compared to non-pregnant sham (*), non-pregnant TAC (†), or pregnant sham rats (‡).