Table I.
Screening laboratory tests for the non-immunology specialist in order to detect patients with possible PIDD
| Possible PIDD | Screening Tests |
|---|---|
| Antibody mediated immunity (AMI) | • CBC and differential |
| • Serum IgG, IgA, IgM | |
| • Antibody titers to protein and polysaccharide vaccines | |
| Cellular mediated immunity (CMI) | • CBC and differential |
| • Lymphocytes: CD3, CD4, and CD8; CD19; CD16/56 | |
| • Chest x-ray | |
| Complement (C) | • C4 (if angioedema without urticaria) |
| • CH50 | |
| Phagocytosis (P) | • Neutrophil counts |
| Neutropenia | • Oxidative burst by DHR test |
| Neutrophil function | |
| Autoimmunity | • ANA, RCP |
| Innate immunity (II) | • Specialized tests (consult an immunologist) |
The screening lab tests should be part of any initial immune evaluation. Only the abbreviations in parentheses will be listed as suggested screening tests in all subsequent tables. HIV testing should be a routine test to exclude AIDS
Abbreviations: ANA antinuclear antibodies, CBC complete blood count, DHR dihydrorhodamine, RCP reactive C protein