Table 3. Risk of HCC associated with SMARCA4 rs11879293 genotypes stratified by Age, Sex, Smoking, Drinking status and HBV infection in combined analysis.
| SMARCA4 rs11879293 | |||||
|---|---|---|---|---|---|
| Variables | GGCases/controls | AG + AACases/controls | OR (95% CI)‡ | P | Pheterogeneity |
| Sex | |||||
| Males | 413/353 | 386/444 | 0.74(0.58–0.95) | 0.019 | 0.790 |
| Females | 101/107 | 90/121 | 0.63(0.39–1.00) | 0.051 | |
| Age | |||||
| ≤60 y | 370/341 | 322/396 | 0.67(0.50–0.91) | 0.011 | 0.980 |
| >60 y | 144/119 | 154/169 | 0.73(0.52–1.03) | 0.076 | |
| Smoking status | |||||
| Nonsmokers | 268/296 | 228/353 | 0.74(0.56–0.99) | 0.042 | 0.564 |
| Smokers | 222/163 | 227/210 | 0.68(0.47–0.97) | 0.033 | |
| Drinking status | |||||
| Nondrinkers | 302/311 | 267/354 | 0.72(0.55–0.95) | 0.019 | 0.599 |
| Drinkers | 187/142 | 188/203 | 0.67(0.44–1.00) | 0.052 | |
| HBsAg | |||||
| Negative | 145/429 | 140/507 | 0.81(0.62–1.07) | 0.142 | 0.093 |
| Positive | 352/22 | 321/41 | 0.47(0.27–0.80) | 0.006 | |
‡ORs and 95% CIs were calculated by unconditional logistic regression after adjusting for sex, age, smoking, drinking and HBsAg, where it was appropriate.