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. 2014 Feb 13;13:23. doi: 10.1186/1475-2859-13-23

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Copyright © 2014 Vanz et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Global view on the ERAD and UPR responses of P. pastoris X-33 during secretory insulin precursor production (after shift from glycerol batch to methanol fed-batch). (Identified) proteins related to UPR and ERAD responses, their function, cellular location and abundance changes during secretory insulin precursor production are indicated. The green arrows (↓) indicate the identified proteins with decreasing abundance, with one arrow indicating small (log2 change 0.6-1) and two arrows strong decreases in abundance (log2 change 1–4).