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Proteasome activity increases in MuRF1 and MAFbx null (KO) mice after 14 days of functional overload (FO). Proteolytic activity of the β5 subunit of the 20S (A) and 26S (B) proteasome was assessed by fluorometric assay in MuRF1 and MAFbx KO mice after no treatment (Con, open bars) or 14 days of functional overload (14d FO, black bars). Data are expressed as a percentage of each respective control value (mean ± SD, n = 4–6/group). *P < 0.05 vs. control.
