FIGURE 5.

Two views of Raptor based on the identification of Raptor-Raptor cross-linked peptides. Because the residues that are cross-linked suggest that they are in close proximity, it is possible to place cross-lined residues closeby. A, a scheme showing a stretched out structure to demonstrate two structured domains. To emphasize the presence of two structured domains, the cross-link between residues 120 and 894 is not shown on this figure. B, a scheme showing a folded structure based on the proximity of residues 120 and 894. Gray circles show the lysine residues that are identified to be cross-linked with 4E-BP1. Black squares show the lysine residues in Raptor that cross-linked with mTOR.