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. 2014 Jan 14;289(8):4762–4777. doi: 10.1074/jbc.M113.530998

FIGURE 8.

FIGURE 8.

Hepatic lipogenesis is independent of PA induction. A and B, expression of mRNA for Acc1 and Fas in primary hepatocytes from wild type (WT) and Agpat2−/− male mice. Acc1 and Fas were analyzed by Q-PCR and normalized to cyclophilin. Shown are the fold-changes compared with untransfected WT primary mouse hepatocytes (expressed as mean ± S.E., n = 4). The expression of both Acc1 and Fas remained unchanged in the presence of C18:1/20:4 PA. C and D, expression of mRNA for Acc1 and Fas in hepatocytes isolated from WT and Agpat2−/− female mice. Acc1 and Fas were analyzed similar to the male mice. The expression of both Acc1 and Fas remained unchanged in the presence of C18:1/20:4 PA. The p values are shown above the bars (*, <0.05).