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. 2013 Dec 26;289(8):4896–4905. doi: 10.1074/jbc.M113.514869

FIGURE 6.

FIGURE 6.

Nox2 and Nox4 mediate cellular hypertrophy. Relative expression of Nox2 (A) and Nox4 mRNA (B) was determined in CnAα−/− kidney fibroblasts transfected with Nox2 or Nox4 cDNA. Data shown are the mean ± S.E. (error bars) of three independent experiments. *, p < 0.05; ***, p < 0.001 compared with vector. C, hypertrophy was measured in Nox2- or Nox4-transfected CnAβ−/− kidney fibroblasts by assessing the protein/DNA ratio. Data shown are the mean ± S.E. of three independent experiments normalized to WT NG vector. *, p < 0.05; ***, p < 0.001. D, ROS generation in Nox2- or Nox4-transfected WT kidney fibroblasts exposed to NG or HG for 48 h was examined by Amplex Red. Data shown are the mean ± S.E. of 8 replicates/group. ***, p < 0.001 compared with NG. ALU, arbitrary light units.