FIGURE 6.

Comparison between binding conformations of GSH analogs and native GSH in solved structures of GST. A, binding of analog I (hexyl-GSH) and GSH in LTC4S from our structure PDB codes 4JCZ and 2UUH, a major shift in the position of the sulfur atom is indicated (7 Å). B, binding of hexyl-GSH and GSH in Δ class GST (adGSTD4-4) from Anopheles dilus (PDB codes 3F63 and 3G7I), C, binding of l-γ-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-l-cysteinylglycine and GSH to microsomal prostaglandin E synthase 1 (mPGES-1; PDB codes 4AL0 and 4AL1). GSH is depicted as a ball-and-stick diagram with a light green backbone, and analogs are shown with a green backbone. Nitrogens are colored blue, oxygens are red, and sulfur is shown in yellow.