FIGURE 1.

Hepatic induction of IFN-λ genes during HCV infection. A and B, total RNA was extracted from liver tissues of healthy and chronic HCV patients for IL-28A/B (A) and IL-29 (B) mRNA quantification by real-time PCR. C–F, human primary hepatocytes were inoculated with UV-irradiated JFH-1 or JFH-1 for the indicated amounts of time, and IFN-λ mRNA levels were quantified by real-time PCR (C and E), whereas protein levels were analyzed by ELISA (D and F). Data represent means ± S.D. of three independent experiments (* indicates p < 0.01).