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. 2013 Nov;49(5):710–720. doi: 10.1165/rcmb.2012-0321OC

Figure 7.

Figure 7.

Effects of environmental exposures on LPS-induced cytokine expression in airway epithelium. Airway epithelial cell cultures established from 1-year-old filtered air–housed or filtered air–housed plus in vivo LPS-exposed were treated with a secondary dose of LPS in vitro. Cultures were compared with age-matched ambient air–housed animals. (A) IL-8 mRNA. (B) IL-8 protein. (C) IL-6 mRNA. (D) IL-6 protein. Each data point represents the mean ± SE from 4–6 animals per group. *P < 0.05, **P < 0.01, and ***P < 0.001, according to two-way ANOVA, environment versus LPS concentration. Diamonds, filtered air; triangles, filtered air + LPS; squares, ambient.