TABLE 1.
QUANTITATIVE OVERVIEW OF BONE LOSS ACCORDING TO MICRO-CT IMAGING
| Parameter | Saline (n = 3) | ODE (n = 4) | LPS (n = 4) | PGN (n = 4) | ANOVA (P Value) |
|---|---|---|---|---|---|
| Bone mineral density (g/mm3) | 0.63 ± 0.03 | 0.48 ± 0.04* | 0.43 ± 0.02*,† | 0.53 ± 0.06* | 0.000 |
| Percent bone volume | 51.38 ± 2.54 | 38.40 ± 2.80* | 34.65 ± 1.86*,† | 43.50 ± 5.46* | 0.000 |
| Specific bone surface (mm−1) | 39.95 ± 4.13 | 48.07 ± 4.21 | 52.76 ± 1.26*,† | 43.79 ± 7.57 | 0.027 |
| Trabecular pattern factor (mm−1) | −0.83 ± 1.93 | 4.75 ± 0.20* | 4.75 ± 1.92* | 2.81 ± 2.57* | 0.008 |
| Structural model index | 0.53 ± 0.27 | 1.09 ± 0.07* | 0.95 ± 0.15* | 0.96 ± 0.22* | 0.012 |
| Trabecular thickness (mm) | 0.091 ± 0.007 | 0.080 ± 0.008 | 0.073 ± 0.002*,† | 0.087 ± 0.011 | 0.042 |
| Trabecular number (mm−1) | 5.64 ± 0.16 | 4.76 ± 0.19* | 4.73 ± 0.26* | 5.01 ± 0.40* | 0.005 |
| Trabecular separation (mm) | 0.11 ± 0.007 | 0.13 ± 0.005 | 0.12 ± 0.004 | 0.12 ± 0.014 | 0.094 |
| Polar moment of inertia (mm4) | 0.0030 ± 0.00010 | 0.0020 ± 0.00017* | 0.0017 ± 0.00008*,†,‡ | 0.0022 ± 0.00027* | 0.000 |
Definition of abbreviations: micro-CT, micro–computed tomography; ODE, organic dust extract; PGN, peptidoglycan.
*P < 0.05, †P < 0.05, and ‡P < 0.05 represent statistical significance versus saline, PGN, and ODE, respectively, using least significance difference (LSD) as post hoc test for multiple comparisons within the groups. Data are represented as means ± SDs.