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. 2013 Dec;49(6):960–970. doi: 10.1165/rcmb.2013-0122OC

Figure 4.

Figure 4.

Foxa2 regulates Alox15 and Alox5 gene promoter activity. Luciferase reporter constructs containing the regulatory region of the mouse Alox15 and Alox5 gene were cotransfected into H441 cells with Foxa2 expression plasmids. Foxa2 significantly inhibited the activity of Alox15, and increased the transcription of Alox5. Foxa2 increased Alox5 gene activity in a dose-dependent manner. IL-13 exerted no effect on Alox15 and Alox5 promoter activity, with or without Foxa2. *P < 0.05, versus Foxa2 control values determined by two-tailed Student t test. #P < 0.05, versus Foxa2 expression plasmids (0.125 and 0.5 μg), according to the Dunnett test (n = 3 in each group). β-gal, β-galactosidase.