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Whole-body plethysmography revealed significantly (A) increased airway hyperresponsiveness (AHR;Penh) and (B) decreased breathing frequency (f) in secondhand smoke–ovalbumin (OVA) mice, compared with all mice from filtered air–OVA groups (‡when we pooled data for females plus males in each exposure set). In addition, there was significantly increased AHR in SOM versus all other groups especially at low methacholine doses (†SOM vs. SOF).
