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The effect of destabilizing the base-pair at position -7 on the kinetics of open complex formation. (A) Examples of the gel images for reactions with the wt promoter and the promoter containing T-G mismatch at position -7. (B) Correlation between the rates of open complex formation and free energy of DNA duplex destabilization due to base analogue substitutions at positions -7 and -13 on the template strand.
