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. Author manuscript; available in PMC: 2014 Feb 21.
Published in final edited form as: Mutat Res. 2012 Oct 29;750(0):121–128. doi: 10.1016/j.mrgentox.2012.10.003

Figure 4.

Figure 4

Mutation pattern of p53 treated with BPQ in wild type, oggl and apn1 yeast. A) Mutation pattern of p53 treated with BPQ in wild type yeast shows that 34% of the mutations were G:C/T:A transversions indicative of increased oxidative DNA damage. Data is plotted with complementary changes below which would reflect a similar change on the other DNA strand. B) Mutation pattern of p53 treated with BPQ in ogg1 yeast shows that 63% of the mutations were G:C/T:A transversions suggesting that Ogg1 is required to repair oxidative damaged caused by BPQ. C) Mutation pattern of p53 treated with BPQ in apn1 yeast shows a high percentage of G:C/T:A transversions as well as a trend toward a strand bias.