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. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Pharmacogenet Genomics. 2014 Feb;24(2):118–128. doi: 10.1097/FPC.0000000000000026

Table 2.

Kinetic parameters of wildtype and variant CYP2A6

	K_m (μM)	V_max (pmol/min/pmol POR)^a	V_max/K_m (nl/min/pmol POR)^a
WT	64 ± 6	5.4 ± 0.1	84 ± 2
CYP2A6.17	57 ± 10	2.2 ± 0.1^***	39 ± 2^***
CYP2A6.39	62 ± 4	1.5 ± 0.1^***	24 ± 2^***
CYP2A6.40	72 ± 6	1.4 ± 0.1^***	19 ± 1^***
CYP2A6.42	55 ± 10	1.5 ± 0.1^***	27 ± 5^***
CYP2A6.43	76 ± 7	3.6 ± 0.1^***	47 ± 5^***
CYP2A6.44	117 ± 13^***	2.3 ± 0.1^***	18 ± 2^***
CYP2A6.45	110 ± 18^***	1.1 ± 0.1^***	9 ± 1^***

^a

POR was used as an internal expression control among the variants.

Parameters are measured ± S.E.M. from three independent experiments

^***

P<0.001