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. 2014 Feb 17;33(1):20. doi: 10.1186/1756-9966-33-20

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Copyright © 2014 Cui et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Negative correlation of miR-34a specific CpG units’ methylation and their expression. (A) Bar plot of Spearman correlation coefficient (r) showing strength of negative correlation between miR-34a expression and methylation value of each CpG unit within miR-34a, with negative values representing inverse correlations and positive values representing positive correlations. Significant correlations (P < 0.05) are indicated in red. (B) Analysis of scatterplots and simple linear regression graphically displaying the correlation between methylation level of each CpG unit and miR-34a gene expression in Kazakh ESCC samples by Spearman correlation coefficient analysis. The straight line was the “best fit” that indicated the trend of relationship.