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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Biol Inorg Chem. 2013 Dec 24;19(2):259–270. doi: 10.1007/s00775-013-1076-3

Table 1.

Epidermal growth factor receptor (EGFR) and HER2 expression rates in cancers

Reference Definition of EGFR overexpression Tumors overexpressing EGFR (%) Reference Definition of HER2 overexpression Tumors overexpressing HER2 (%)
Onn et al. [145] 2 or 3 staining by IHC 60 Slamon et al. [151] Twofold or more HER2 gene by Southern blotting 30
Selvaggi et al. [146] 2+ or 3+ staining by IHC 37 Paik et al. [152] Definite membrane staining by IHC in tumor cell 29
Ohtsuka et al. [147] 2+ or 3+ by Western blotting 40 Owens et al. [153] Twofold or more of HER2 gene by FISH 23
Dancer et al. [148] Twofold or more EGFR gene by FISH 65 Owens et al. [153] 2+ or higher result by IHC 20
Bloomston et al. [149] 1+ or higher staining by IHC 69 Seshadri et al. [154] Twofold or more HER2 gene by slot blotting 21
Thybusch-Bernhardt et al. [150] Positive staining by IHC 33 Andrulis et al. [155] Twofold or more HER2 gene by RT-PCR 20

FISH fluorescent in situ hybridization, IHC immunohistochemistry, RT-PCR real-time polymerase chain reaction