Figure 1.

CD105⁺ cells in NOD islets. A: Single-cell suspension of handpicked islets was prepared from four to six NOD mice (8 weeks old) and was analyzed by flow cytometry. CD45⁻ stromal cells are shown at the right. B: Immunohistochemical staining for CD105 (top) and CD31 (bottom) in mouse pancreata isolated from 8-week-old NOD mice. Islets were grouped based on their levels of lymphocyte infiltration: normal, peri-insulitis, and insulitis. Data represent three to four independent experiments. SSC-H, side scatter height.