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. 2014 Feb 13;63(3):994–1007. doi: 10.2337/db13-1013

Figure 1.

Figure 1

Decreased insulin secretion but unaltered insulin sensitivity after pancreatoduodenectomy. A: Schematic of the hyperglycemic clamp experiment. l-arginine bolus (5 g) was injected at 120 min. B: Insulin secretion during hyperglycemic clamp. C: Changes in the AUC of first-phase, second-phase, and phase of insulin secretion after l-arginine stimulus (Arginine) detected during hyperglycemic clamp. A significant reduction was found in all phases of insulin secretion. D: Hyperinsulinemic euglycemic clamp performed before and after surgery. E: Mixed-meal test performed before and after surgery. Changes in the AUC of GLP-1, GIP, and glucagon. *P < 0.05, **P ≤ 0.001.