Figure 2.

After pancreatoduodenectomy, insulin-resistant subjects exhibited a reduction in insulin secretion and an increase in glucagon secretion. A: AUC of insulin secretion evaluated during the hyperglycemic clamp before and after surgery in insulin-sensitive and insulin-resistant subjects. Insulin secretion was reduced in both groups and for all of the insulin-secretion phases. B: AUC of glucagon secretion evaluated during the mixed-meal test before and after surgery in insulin-sensitive and insulin-resistant subjects. C: Absolute reductions from baseline (before surgery) in insulin secretion AUCs during the hyperglycemic clamp. D: Absolute increases from baseline (before surgery) in glucagon secretion AUCs during the mixed-meal test. *P < 0.05.