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. Author manuscript; available in PMC: 2015 Feb 13.
Published in final edited form as: Nature. 2014 Jan 12;506(7487):191–196. doi: 10.1038/nature12944

Fig. 2. Structure of the human δ-OR ICL3.

Fig. 2

(a) 2mFo- DFcelectron density map (grey mesh) of BRIL-δOR(ΔN/ΔC)-naltrindole ICL3 contoured at 1σ. Polar and ionic interactions of Arg2576.31 shown by orange dashed lines (b) ICL3 loop comparison between BRIL-δOR(ΔN/ΔC)-naltrindole (green) and NOP12 (light grey) structures. Hydrophobic residues in the ICL3 hydrophobic cluster are shown as orange spheres and OLA molecules are represented by yellow sticks. (c) ICL3 comparison of BRIL-δOR(ΔN/ΔC)-naltrindole (green) with A2AAR (magenta; PDB ID 3PWH) and Rhodopsin (white; PDB ID 3CAP). (d) Details of the hydrogen bonds between Arg2395.66, Leu246ICL3, Val1503.54 and water molecule (red sphere) shown by grey dashed lines