Table 1.

Human class B G protein coupled receptors.

^aThe coloring scheme was chosen to give each subfamily of class B GPCRs a different color.

^bPDB IDs of corresponding crystal structures (bold) and NMR structures (italics) of apo ECD and TMD (underlined) are indicated between parentheses;

^ccrystal structure of RAMP2 unit;

^dComplex with telcagepant;

^eComplex with olcegepant;

^fcrystal structure of assembly of CLR and RAMP1 units;

^gThe most potent endogenous agonists are given;

^hPDB IDs of corresponding crystal structures (bold) and NMR structures (Italics) of ECD-peptide agonist complexes are indicated between parentheses;

ⁱAmino acid sequences of peptide ligands and systematic names of non-peptide molecules are provided in Supporting Table S1;

^jα-helical cyclic CRF;

^kDrug on the market;

^lReached clinical Phase 3 but discontinued;

^mIn clinical Phase 3;

ⁿIn clinical Phase 2;

^oIn clinical Phase 1;

Abbreviations: AMY amylin, CRF corticotropin-releasing factor, CGRP calcitonin gene related peptide, CLR calcitonin like receptor, CT calcitonin, GHRH growth hormone releasing hormone, GIP glucose dependent insulinotropic peptide, GLP glucagon like peptide, PTH parathyroid hormone, PTHrP parathyroid hormone related protein, TIP tuberoinfundibular peptide, VIP vasoactive intestinal peptide, Ucn urocortin.