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Optimization of the cancer cell-based high-throughput screening (HTS) assay in 96-well and 384-well formats. (A) The Z-factor was first established in 96-well format using PC3-MM2 cells treated with 25 μM 174 (■) or vehicle control (●, 0.125% DMSO). The resulting 96-well-format Z-factor was 0.7, with a signal-to-noise ratio (S/N) of 10. (B) After miniaturizing the cancer cell-based assay to a 384-well format, the Z-factor and S/N observed were 0.5 and 7, respectively.
