Table 1.
List of nuclei positive for the IL-2 transgene throughout the rostral-caudal extent of the brain and brainstem. (+) symbol designates relative intensity of GFP staining as visualized by fluorescence immunohistochemistry.
| Nucleus | Modality | Relative staining intensity |
|---|---|---|
| Mitral cell layer olfactory bulb | Olfactory | ++ |
| Granular cell layer olfactory bulb | Olfactory | +++ |
| External piriform layer olfactory bulb | Olfactory | ++ |
| Anterior olfactory nucleus (ventral and medial) | Olfactory | ++ |
| Ventral and lateral orbital cortices | Limbic | ++ |
| Cingulate | Limbic | ++++ |
| Motor 1 | Motor | ++ |
| Motor 2 | Motor | ++ |
| Dorsal endopiriform nucleus | Sensory motor gating (SMG) | ++++ |
| Striatum | Motor, SMG | + |
| Lateral septum | Limbic, SMG | ++++ |
| Medial septum | Limbic | ++ |
| Horizontal limb diagonal band of Broca | Limbic | ++ |
| Subiculum | Limbic | + |
| Paraventricular hypothalamic nucleus | Limbic, Autonomic | +++ |
| Basal lateral amygdaloid nucleus | Limbic | + |
| Anterior and posterior hypothalamus | Autonomic | ++ |
| Ventrolateral geniculate nucleus, parvocellular | Vision | +++ |
| Nucleus of the solitary tract | Chemosensation | ++++ |
| Periaqueductal gray | Analgesia | ++ |
| Median raphe nucleus | Analgesia | ++ |
| Magnocellular reticular formation/ Gigantocellular reticular formation | Mixed | ++++ |
| Red nucleus | Motor | ++++ |
| Entorhinal cortex (medial/lateral) | Spatial memory, SMG | ++++ |
| Mammillary bodies | Memory | ++++ |
| Mesencephalic nucleus of 5 | Proprioception, Motor | ++ |
| Pontine gray | Relay | ++ |
| Lateral vestibular nucleus | Proprioception, Motor | +++ |
| Fastigial nucleus cerebellum | Proprioception, Motor | ++++ |
| Posterior interposed nucleus | Proprioception, Motor | ++++ |
| Inferior olivary nucleus | Proprioception, Motor | +++ |