Table 1.
Clinical and radiological data for two morphological groups of ganglioglioma
| |
Pathology group |
Age @ diagNosis (years) |
Gender |
Dominant site of tumor |
BRAF: p.V600E |
BRAF duplication |
KIAA1549-BRAF fusion gene
|
Neuroimaging |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Midline location | Circumscribed | Cysts/necrosis | Hemorrhage | Enhancement | Edema | Restricted diffusion | ||||||||
| GG01 |
I |
6 |
M |
Cerebellar hemisphere |
Yes |
No |
No |
No |
No |
0 |
0 |
+ |
+ |
No |
| GG02 |
I |
9 |
F |
Cerebellum |
Yes |
No |
No |
n/a |
||||||
| GG03 |
I |
21 |
F |
Cerebellar hemisphere |
Yes |
No |
No |
No |
Yes |
0 |
0 |
++ |
+++ |
Yes |
| GG04 |
I |
9 |
F |
Medulla |
Yes |
No |
n/a |
No |
No |
0 |
0 |
+++ |
0 |
No |
| GG05 |
I |
8 |
F |
Medulla |
Yes |
No |
n/a |
No |
Yes |
0 |
0 |
++ |
0 |
n/a |
| GG06 |
I |
8 |
M |
Medulla |
Yes |
No |
n/a |
No |
No |
0 |
0 |
+++ |
+ |
Yes |
| GG07 |
I |
15 |
F |
MCP |
Yes |
No |
No |
No |
No |
0 |
0 |
+++ |
++ |
No |
| GG08 |
I |
8 |
F |
Cerebellar hemisphere |
No |
No |
No |
No |
No |
+++ |
0 |
+ |
0 |
No |
| GG09 |
I |
11 |
F |
MCP |
No |
No |
n/a |
No |
Yes |
0 |
0 |
++++ |
0 |
n/a |
| GG10 |
I |
11 |
F |
Medulla |
No |
No |
n/a |
No |
No |
0 |
0 |
++ |
++ |
n/a |
| GG11 |
I |
12 |
M |
Medulla |
No |
No |
No |
No |
No |
0 |
0 |
+++ |
++ |
Yes |
| GG12 |
I |
1.8 |
M |
Pons |
No |
No |
No |
No |
No |
0 |
0 |
+ |
++ |
No |
| GG13 |
I |
21 |
M |
MCP |
No |
No |
No |
No |
No |
+ |
0 |
+++ |
+ |
n/a |
| GG14 |
I |
0.6 |
M |
MCP |
No |
No |
No |
No |
No |
0 |
0 |
+ |
+ |
No |
| GG15 |
I |
15 |
F |
Cervico-medullary |
No |
No |
No |
n/a |
||||||
| GG16 |
I |
14 |
M |
Medulla |
No |
No |
No |
No |
No |
0 |
0 |
++++ |
++ |
No |
| GG17 |
II |
12 |
M |
Vermis |
No |
Yes |
Yes - ex16:ex9 |
No |
Yes |
++ |
0 |
+ |
0 |
Yes |
| GG18 |
II |
4 |
F |
Vermis |
No |
Yes |
Yes - ex15:ex9 |
Yes |
Yes |
+ |
+ |
+++ |
+ |
Yes |
| GG19 |
II |
12 |
F |
Cord (thoraco-lumbar) |
No |
Yes |
Yes - ex15:ex9 |
Yes |
No |
+ |
+ |
++ |
0 |
n/a |
| GG20 |
II |
16 |
F |
Cord (cervico-thoracic) |
No |
Yes |
Yes - ex15:ex9 |
Yes |
Yes |
+++ |
0 |
++ |
+++ |
n/a |
| GG21 |
II |
18 |
M |
Cord (cervico-thoracic) |
No |
Yes |
Yes - ex15:ex9 |
Yes |
No |
+++ |
+ |
+ |
++++ |
n/a |
| GG22 |
II |
9 |
F |
Vermis |
No |
Yes |
Yes - ex15:ex9 |
No |
Yes |
++ |
0 |
+++ |
++ |
No |
| GG23 |
II |
17 |
F |
Vermis |
No |
Yes |
Yes - ex16:ex9 |
No |
Yes |
++ |
+ |
+ |
++ |
Yes |
| GG24 |
II |
10 |
M |
Cord (cervical) |
No |
Yes |
Yes - ex16:ex11 |
Yes |
Yes |
+++ |
+ |
++ |
++ |
n/a |
| GG25 |
II |
9 |
M |
Vermis |
No |
Yes |
Yes - ex16:ex11 |
Yes |
No |
++++ |
0 |
++++ |
+ |
Yes |
| GG26 |
II |
4 |
M |
Medulla |
No |
No |
No |
No |
No |
0 |
0 |
+++ |
++ |
Yes |
| GG27 | II | 9 | M | Midbrain | No | No | No | No | Yes | +++ | 0 | + | ++ | n/a |
M = male; F = female.
MCP = middle cerebellar peduncle.
n/a = Not available.
0 - ++++; magnitude scale.