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. 2014 Feb 19;34(8):2768–2773. doi: 10.1523/JNEUROSCI.4402-13.2014

Figure 4.

Figure 4.

Effects of a single oral dose (0.75 mg/kg) of MPH on PNE induced spontaneous locomotor activity in male and female F3 mice derived from female F2 founders. Locomotor activity was assayed from 17:00–09:00 h (A, B). MPH or saline (SAL) was gavaged at 19:00 h. Cumulative activity (C) was analyzed for the 12 h lights-off period from 19:00 to 07:00 h. Data are shown as mean ± SEM values. Hourly measurements showed that both male (A) and female (B) F3 mice showed lower activity upon MPH administration compared with SAL administration. Cumulative activity over the 12 h lights-off period showed significant decreases in the PNE male and female mice (C) receiving MPH compared with SAL. Statistical analysis (t test) showed significant decreases in cumulative activity in male and female mice administered MPH compared with their counterparts receiving SAL (male: t = 3.39, p = 0.04; female: t = 6.09, p = 0.01; n = 4 per group).