Table 3. Number of lung cancer recurrences and/or progressions by location and ALK statusa.
| ALK+ (n=22)b | ALK– (n=277) | |||
|---|---|---|---|---|
|
| ||||
| IHC2+ (n=12) | IHC1+ (n=63) | IHC0 (n=202)b | ||
| No recurrence or progression, n (%) | 6 (30·0) | 7 (58·3) | 46 (73·0) | 153 (76·1) |
| Number in intrathoracic regionc, n (%) | ||||
| 1 | 4 (20·0) | 1 (8·3) | 8 (12·7) | 17 (8·5) |
| 2+ | 4 (20·0) | 3 (25·0) | 6 (9·5) | 21 (10·4) |
| Number in same lung, n (%) | ||||
| 1 | 4 (20·0) | 3 (25·0) | 9 (14·3) | 26 (12·9) |
| 2+ | 2 (10·0) | 0 (0·0) | 4 (6·4) | 8 (4·0) |
| Number in other lung, n (%) | ||||
| 1 | 1 (5·0) | 2 (16·7) | 3 (4·8) | 14 (7·0) |
| 2+ | 2 (10·0) | 1 (8·3) | 3 (4·8) | 7 (3·5) |
| Number in chest cavityd, n (%) | ||||
| 1 | 3 (15·0) | 2 (16·7) | 2 (3·2) | 6 (3·0) |
| 2+ | 0 (0·0) | 0 (0·0) | 0 (0·0) | 3 (1·5) |
| Number in extrathoracic regione, n (%) | ||||
| 1 | 6 (30·0) | 2 (16·7) | 6 (9·5) | 16 (8·0) |
| 2+ | 3 (15·0) | 1 (8·3) | 3 (4·8) | 9 (4·5) |
| Number in brain, n (%) | ||||
| 1 | 4 (20·0) | 3 (25·0) | 3 (4·7) | 9 (4·5) |
| 2+ | 1 (5·0) | 0 (0·0) | 0 (0·0) | 1 (0·5) |
| Number in bonesf, n (%) | ||||
| 1 | 2 (10·0) | 1 (8·3) | 3 (4·8) | 8 (4·0) |
| 2+ | 0 (0·0) | 0 (0·0) | 1 (1·6) | 4 (2·0) |
| Number in liver, n (%) | ||||
| 1 | 2 (10·0) | 0 (0·0) | 0 (0·0) | 3 (1·5) |
| 2+ | 0 (0·0) | 0 (0·0) | 1 (1·6) | 0 (0·0) |
| Number in kidneys, n (%) | ||||
| 1 | 1 (5·0) | 0 (0·0) | 0 (0·0) | 0 (0·0) |
| Number in adrenal glands, n (%) | ||||
| 1 | 0 (0·0) | 0 (0·0) | 0 (0·0) | 2 (1·0) |
| Number in other sitesg, n (%) | ||||
| 1 | 3 (15·0) | 0 (0·0) | 1 (1·6) | 6 (3·0) |
| 2+ | 0 (0·0) | 0 (0·0) | 1 (1·6) | 2 (1·0) |
n=299 cases in the survival cohort.
Anaplastic lymphoma kinase (ALK)+ is fluorescence in-situ hybridization (FISH)+ and/or immunohistochemistry (IHC)3+, and ALK– is FISH– and/or IHC0/1+ (included in ALK+ if FISH+ and IHC1+).
Two ALK+ cases and one IHC0 case have unknown locations for their recurrences and/or progressions; reported percentages are out of n=20 ALK+ cases and n=201 IHC0 cases.
Intrathoracic – includes same lung, other lung, and chest cavity.
Chest cavity – includes mediastinum, pleural effusion, pleural nodes, and pericardium.
Extrathoracic – includes brain, bones (including ribs), liver, kidneys, adrenal glands, and other sites.
Bones – includes all bones of the body, including ribs.
Other sites – includes all areas of the body not otherwise specified.