Table 1.

³¹P-MRS Results

	Muscle pHi	Muscle PCr (rest)	Muscle PCr-R (τ)	Frontal PCr
Case 1	7.020	0.415	Not interpretable	0.122
Control 1	7.068	0.433	43.2	0.146
Case 2	7.044	0.396	Not completed	Not completed
Control 2	7.052	0.408	19.8	0.148
Case 3	6.997	0.389	Not completed	0.132
Control 3	7.028	0.446	28.1	0.120
Case 4	7.012	0.423	30.9	0.100
Control 4	7.028	0.463	29.3	0.139
Case 5	7.020	0.448	32.4	0.126
Control 5	7.052	0.476	30.0	Not interpretable
Case 6	6.989	0.489	26.2	0.162
Control 6	7.028	0.434	22.2	0.163
#Expected: #Contrary (Sign of case-control difference)	6:0	5:1	3:0	3:1
1-sided p (sign test)	0.016	0.11	0.125	0.31
1-sided p (paired t-test)	0.0024	0.17	0.031	0.17

PCr = phosphocreatine; PCr-R = phosphocreatine recovery following exercise; pHi = intracellular pH.

^*Phosphocreatine is in ratio to total peaks (a fraction of total signal)

Except for case 2, intracellular pH of each case is lower than that of any control.