Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 15;7:289–295. doi: 10.2147/OTT.S58089

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Yuki et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Expressions of phosphorylate Akt (Ser-473).

Notes: (A) Expression of phosphorylated Akt (Ser-473) (60 kDa) and beta-actin (42 kDa) proteins in the primary tumor tissues using Western blotting. Each number corresponds to a case number, representative case of ccRCC, other RCC with sarcomatoid differentiation (sRCC1 and sRCC2), and present sRCC case. Patients of ccRCC and sRCC1/sRCC2 underwent nephrectomy before receiving any other therapy. Compared to ccRCC, tumor tissues of sRCCs showed higher expression of phosphorylated Akt (Ser-473). In the present sRCC case treated with presurgical axitinib, some tumor tissues of T4-2 and T4-3 showed an extremely lower expression of phosphorylated Akt (Ser-473) than T4-1, indicating that the T4-2 and T4-3 tissues were sensitive to axitinib. (B) Expression of phosphorylated Akt (Ser-473) in the primary tumors by densitometric analysis, as described previously.⁶ The data show the 95% confidence interval. Expression of phosphorylated Akt (Ser-473) was increased in sRCC tumor tissue (n=3; mean ± SD =8.66±2.43) compared with those in ccRCC (n=5; 2.16±0.47; P=0.0253).

Abbreviations: p, phosphorylated; M, marker; N, non-tumor tissue; n, number of the patients analyzed; T, primary tumor tissue with metastatic lesions; RCC, renal cell carcinoma; ccRCC, clear cell renal cell carcinoma; sRCC, renal cell carcinoma with sarcomatoid differentiation; SD, standard deviation.