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. 2014 Feb 15;7:289–295. doi: 10.2147/OTT.S58089

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© 2014 Yuki et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Representative immunohistochemistry in the primary tumor tissues for antiphosphorylated Akt (Ser-473) antibody.

Notes: Some of the tumor cells of ccRCC (A) showed brown staining in a membrane and cytoplasm, while many of the tumor cells did not. Most of the tumor cells of sRCC1 (B) and sRCC2 (C) showed moderate to strong staining. In the present sRCC case treated with presurgical axitinib, some of the tumor cells of T4-1 (D) showed weak reaction.

Abbreviations: ccRCC, clear cell renal cell carcinoma; sRCC, renal cell carcinoma with sarcomatoid differentiation.