Table 1. Comparison of canine CNG channel properties to human CNG channels.

cGMP		cAMP		IcAMP/IcGMP	Idil/I	References
K0.5 (µM)	Nh	K0.5 (µM)	Nh
cA3
10.3±1.24 (7)	2.40±0.33	1665±226 (7)	2.06±0.30	0.19±0.01 (16)	0.79±0.05 (4)	This work
hA3
13.5±2.5 (39)*	2.2±0.2	1329±3.69 (39)	1.3±0.2	0.12±0.04 (39)	0.94±0.04 (6)	[6]
12.9±0.5 (62)*	2.1	1212±37 (53)	1.4	0.12±0.01 (48)		[25]
8.20±0.34 (7)	1.90±0.13	580±110 (10)	1.39±0.37			[69]
11.1±1.0 (13)	1.83±0.19					[24]
8.63±0.81 (21)	1.53±0.17					[26]
cA3+ hB3
16.0±1.05 (6)	1.87±0.15	1569±262 (6)	2.36±0.66	0.33±0.02 (25)	0.40±0.02 (8)	This work
hA3+ hB3
19.9±3.8 (56)*	2.0±0.2	897±1.77 (56)	1.6±0.2	0.27±0.09 (59)	0.26±0.11(15)	[6]
15.8±0.3 (61)*	2.0±0.2	846±33 (54)	1.5±0.3	0.36±0.01 (48)		[25]
19.4±1.6 (6)	1.65±0.18	570±60 (6)	1.03±0.13			[69]
26.2±1.9 (16)	1.82±0.11					[24]
18.2±1.84 (13)	1.22±0.15					[26]

The K_0.5 values, Hill coefficients (N_h), cAMP efficacy (I_cAMP/I_cGMP), and L-cis Diltiazem block (I_dil/I) of homomeric and heteromeric channels were determined at −60 mV. Averaged calcium to sodium permeability rations were calculated to be 1.52±0.52 (n = 5) for cA3 and 17.7±6.4 for A3+ B3 (n = 4). Comparison permeability ratios for hA3 were not available. Statistical values were SEM except for the two reports indicated with an * which were SD values.