Figure 3. Representative kinetics of TcapQ488 activation in vivo.

In vivo images were taken in a rat eye pretreated with 12.5 mM NMDA immediately before (A) and at 4 hours (B), 12 hours (C), 25 hours (D), 48 hours (E) and 72 hours (F) post intravitreal injection of 0.313 nmol TcapQ488. Evidence of initial probe activation was noted at 4 hours after TcapQ488 injection (B). Scale bar, 200 µm in all images.