Figure 6. IL-12Rβ2+ and IL-23R+ innate immune cells both contribute to the systemic inflammatory response.

C57BL/6.Rag1^−/−, IL-23R^−/−.Rag1^−/−, and IL-12Rβ2^−/−.Rag1^−/− mice were injected with anti-CD40 antibody or PBS (6 to 11 mice per group). (A) Mouse weight relative to the initial weight is shown. a, b p<0.05. (B) Day 7 serum concentrations of IFN-γ, IL-1β, IL-6, IL-12p70, IL-18, IL-23p19, TNF-α, CCL-2 and CXCL1 were quantified. Each symbol represents data for one mouse. *p<0.05, **p<0.01.