Figure 1.

(A and B) Components of the principal reward neurocircuitries in the brain. (A) Neuroanatomical location of reward circuitry; (B) schematic of reward circuitry with primary neurotransmitter projections.

Note: Frontal cortex includes prefrontal, orbitofrontal, and anterior cingulate cortex.

Abbreviations: AMG, amygdala; DA, dopaminergic neurons; DS, dorsal striatum; GABA, γ-aminobutyric acid; Glu, glutamatergic neurons; HPC, hippocampus; MSN, medium spiny neurons; NAc, nucleus accumbens; PFC, prefrontal cortex; VTA, ventral tegmental area.