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. 2014 Feb 21;9(2):e89113. doi: 10.1371/journal.pone.0089113

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© 2014 Vladimir E

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panel A: Simulated [Ca²⁺]_i transients as function of time for control conditions show clear negative staircase effect. Panel B: Simulated [Ca²⁺]_i transients as function of time after 1 µM isoproterenol application at t = 0 s does not show negative staircase effect. In both panels, stimulation frequency is 1 Hz.