Table 1. Simulated and experimental prolongations (in %) of the action potentials in mouse ventricular myocytes at different repolarizations and stimulation frequencies (1 µM Iso).
APD25, ms | APD50, ms | APD75, ms | APD90, ms | |
Experimental values | ||||
Wu et al. [126] * | 13.5±4 | 5±7 | ||
Tong et al. [125] ** | 18 | 9 | ||
Tong et al. [125] *** | 38 | 28 | ||
Wang et al. [75] **** | 48 | 51 | ||
Simulated values (this paper) | ||||
1 Hz | 7.65 | 21.67 | 19.10 | 14.90 |
2 Hz | 8.09 | 22.58 | 17.20 | 15.95 |
3 Hz | 9.14 | 24.76 | 18.77 | 16.73 |
4 Hz | 9.04 | 26.09 | 18.04 | 13,16 |
5 Hz | 8.33 | 27.27 | 17.00 | 10.37 |
* Experimental data are obtained at 0.5 Hz stimulation and 2 µM isoproterenol.
** Experimental data are obtained at 2 Hz stimulation.
*** Experimental data are obtained at 4 Hz stimulation.
**** Experimental data are obtained at 1 Hz stimulation.