Table 2. Genotype and allele frequency of ABCB1 and ABCG2 SNPs in AED resistant and responsive cohorts.
| SNP | Cohort | TT | TC | CC | P-value* | T | C | OR | 95% C.I | P-value* |
| ABCB1 | AED RESISTANT | 240 (0.94) | 15 (0.06) | 0 | 0.61 | 495 (0.97) | 15 (0.03) | 1.209 | 0.58–2.54 | 0.70 |
| rs3213619 | AED RESPONSIVE | 184 (0.93) | 14 (0.07) | 0 | 382 (0.965) | 14 (0.035) | ||||
| GG | GA | AA | G | A | ||||||
| ABCB1 | AED RESISTANT | 247(0.965) | 8 (0.031) | 1 (0.004) | 0.32 | 502 (0.98) | 10 (0.02) | 1.966 | 0.87–4.42 | 0.10 |
| rs2214102 | AED RESPONSIVE | 186 (0.935) | 11 (0.055) | 2 (0.01) | 383 (0.96) | 15 (0.04) | ||||
| CC | CT | TT | C | T | ||||||
| ABCB1 | AED RESISTANT | 39(0.150 | 138 (0.53) | 82 (0.32) | 0.34 | 216 (0.42) | 302 (0.58) | 1.205 | 0.92–1.57 | 0.17 |
| rs1202168 | AED RESPONSIVE | 25(0.125) | 99 (0.495) | 76 (0.38) | 149 (0.37) | 251 (0.63) | ||||
| CC | CT | TT | C | T | ||||||
| ABCB1 | AED RESISTANT | 32(0.12) | 110(0.43) | 117(0.45) | 0.68 | 174 (0.34) | 344 (0.66) | 0.982 | 0.74–1.29 | 0.94 |
| rs1128503 | AED RESPONSIVE | 29(0.145) | 78(0.39) | 93(0.465) | 136 (0.34) | 264 (0.66) | ||||
| TT | TA | AA | T | A | ||||||
| ABCB1 | AED RESISTANT | 152 (0.60) | 98 (0.38) | 6 (0.02) | 0.98 | 402 (0.785) | 110 (0.215) | 1.029 | 0.75–1.41 | 0.87 |
| rs1922242 | AED RESPONSIVE | 116 (0.59) | 77 (0.39) | 5 (0.02) | 309 (0.78) | 87 (0.22) | ||||
| GG | GT | TT | G | T | ||||||
| ABCB1 | AED RESISTANT | 29 (0.11) | 129 (0.51) | 98 (0.38) | 0.28 | 187 (0.365) | 325 (0.635) | 1.015 | 0.77–1.33 | 0.94 |
| rs2032582 | AED RESPONSIVE | 29 (0.15) | 86 (0.43) | 84 (0.42) | 144 (0.36) | 254 (0.64) | ||||
| CC | CT | TT | C | T | ||||||
| ABCB1 | AED RESISTANT | 12 (0.05) | 136 (0.52) | 111 (0.43) | 0.70 | 160 (0.31) | 358 (0.69) | 1.106 | 0.84–1.46 | 0.52 |
| rs1045642 | AED RESPONSIVE | 12 (0.06) | 109 (0.54) | 80 (0.40) | 133 (0.33) | 269 (0.67) | ||||
| AA | AG | GG | A | G | ||||||
| ABCG2 | AED RESISTANT | 6 (0.02) | 54 (0.23) | 179 (0.75) | 0.27 | 66 (0.14) | 412 (0.86) | 0.926 | 0.63–1.35 | 0.70 |
| rs2231137 | AED RESPONSIVE | 2 (0.01) | 55 (0.275) | 143 (0.715) | 59 (0.15) | 341 (0.85) | ||||
| CC | AC | AA | C | A | ||||||
| ABCG2 | AED RESISTANT | 190 (0.79) | 45 (0.19) | 4 (0.02) | 0.82 | 425 (0.89) | 53 (0.11) | 0.901 | 0.58–1.39 | 0.66 |
| rs2231142 | AED RESPONSIVE | 160 (0.81) | 36 (0.18) | 2 (0.01) | 356 (0.90) | 40 (0.10) |
OR, Odds ratio; CI, Confidence Interval.
*uncorrected p-value.