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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Rev Endocr Metab Disord. 2014 Jun;15(2):111–123. doi: 10.1007/s11154-013-9255-7

Figure 1. Schematic of CTRPs.

Figure 1

With the exception of CTRP4, every CTRP consists of four domains: a signal peptide for secretion (dark grey), an N-terminal domain with one or more conserved Cys residues (white), a collagen domain with varying numbers of Gly-X–Y repeats (light gray), and a C-terminal globular domain homologous to the immune complement C1q (blue). The numbers on the right refer to the percent amino acid identity between human and mouse orthologs when comparing the full-length protein (first column) or the C-terminal globular domain (second column). CTRP4 and CTRP8 are omitted—the former consists of only two tandem C1q domains, while the latter is absent in the mouse genome.