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. 2014 Feb 21;9(2):e89534. doi: 10.1371/journal.pone.0089534

Figure 3. Influence of exosomes on sensitivity of cells to cisplatin.

Figure 3

(A) Pretreatment of A549 cells with exosomes released during cisplatin (3 µg/mL) exposure decreases the sensitivity of cells to cisplatin by about 20% compared with those without pretreatment for 48 h. (B) Uptake of exosomes (red) by A549 cells after incubation for 3 h was visualized by microscopy. Scale bar: 50 µm. (C) Microscopic image of A549 cells cultured under four conditions [control, exosomes, DDP (3 µg/mL), exosomes+DDP] for 48 h. Images were obtained at a magnification of 100×. *in (A) indicates p<0.05 versus control groups.