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. 2014 Feb 21;9(2):e89743. doi: 10.1371/journal.pone.0089743

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© 2014 Atanassoff et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–C) The SLO-perforated protrusions of SH-SY5Y or HEK 293 cells are wrenched apart by mechanical forces. (A) The global translocation of annexin A1-YFP manifests cell lysis. (B,C) The cytoplasmic localization of annexin A1-YFP within the cell body is evidence of successful resealing of the plasmalemma. The arrow in (B) points at the resealed base of the destroyed protrusion. The asterisks in (B,C) denote regions of clear demarcation between permeabilized (plasmalemmal localization of annexin A1-YFP) and non-permeabilized (cytoplasmic localization of annexin A1-YFP) cellular compartments. Magnification bars = 5 µm.