Figure 8. Microvesicle shedding is responsible for the initial elimination of toxin pores whereas lysosomal repair mends secondary, self-inflicted mechanical injuries.

(A) Individual experiments in which SH-SY5Y cells either repaired efficiently (low damage; 72 cells, 3 independent experiments) or suffered from extensive plasmalemmal damage (high damage; 66 cells, 3 independent experiments) were analyzed for: (B) amount of microvesicles released per cell, (C) percentage of cells that suffered from secondary, self-inflicted mechanical damage (100% = total number of cells in each individual experiment), (D) percentage of cells that recovered after self-inflicted mechanical damage (100% = number of mechanically-damaged cells in each individual experiment), (E) contribution of lysosomal repair to total repair (100% = total number of repaired cells in each individual experiment). **p<0.001, *p<0.01.