Fig. 3.

a Concentrations of 4-OH (top left), endoxifen (top middle) and DMT (top right) in tumor recurrent and non-recurrent patients. Data are presented as mean ± SEM. The concentrations of each metabolite were significantly higher in patients without breast tumor recurrence. *p < 0.05 relative to tumor recurrence for 4-OH and endoxifen. **p < 0.01 for DMT. b The concentration ratios of endoxifen to 4-OH (bottom left) and DMT to TAM (bottom right) for two groups of breast cancer patients. The ratios for patients without tumor recurrence were significantly higher comparing to the recurrent group. Data are presented as mean ± SEM. **p < 0.01 relative to tumor recurrence